E-ISSN 2149-388X | ISSN 2149-0430
 

Meta-Analysis 


Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Shao-Huan Lan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, Tzu-Liang Hsu.

Abstract
This meta-analysis assessed the efficacy and safety of iclaprim compared with those of vancomycin in the treatment of acute bacterial skin and skin structure infection (ABSSSI). Only randomized controlled trials (RCTs) comparing the effect of iclaprim with vancomycin on adult patients with ABSSSIs were included. A total of 3 RCTs involving 1260 adult patients with ABSSSIs were enrolled. Iclaprim had a non-inferior clinical response rate compared with vancomycin. Similar trend was observed in the following subgroups: major cutaneous abscesses, cellulitis/erysipelas, wound infections, MRSA, MSSA, Streptococcus pyogenes infections. Finally, no differences were observed between iclaprim and vancomycin regarding the risks of any AE, drug-related AE, severe AE, discontinuation of study drug due to AE, and mortality. In conclusion, iclaprim exhibits non-inferior efficacy compared with vancomycin in the treatment of ABSSSI. Additionally, iclaprim was generally as well tolerated as vancomycin.

Key words: Iclaprim, vancomycin, acute bacterial skin and skin structure infection


 
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How to Cite this Article
Pubmed Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. 2022; 8(3): 100-109. doi:10.5455/umj.20220613080211


Web Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. https://www.ulutasmedicaljournal.com/?mno=55300 [Access: September 14, 2022]. doi:10.5455/umj.20220613080211


AMA (American Medical Association) Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. 2022; 8(3): 100-109. doi:10.5455/umj.20220613080211



Vancouver/ICMJE Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. (2022), [cited September 14, 2022]; 8(3): 100-109. doi:10.5455/umj.20220613080211



Harvard Style

Lan, S., Chao, . C., Chang, . S., Lu, . L. & Hsu, . T. (2022) Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J, 8 (3), 100-109. doi:10.5455/umj.20220613080211



Turabian Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. 2022. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. THE ULUTAS MEDICAL JOURNAL, 8 (3), 100-109. doi:10.5455/umj.20220613080211



Chicago Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. "Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials." THE ULUTAS MEDICAL JOURNAL 8 (2022), 100-109. doi:10.5455/umj.20220613080211



MLA (The Modern Language Association) Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. "Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials." THE ULUTAS MEDICAL JOURNAL 8.3 (2022), 100-109. Print. doi:10.5455/umj.20220613080211



APA (American Psychological Association) Style

Lan, S., Chao, . C., Chang, . S., Lu, . L. & Hsu, . T. (2022) Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. THE ULUTAS MEDICAL JOURNAL, 8 (3), 100-109. doi:10.5455/umj.20220613080211