E-ISSN 2149-388X | ISSN 2149-0430
 
2023, Vol: 9, Issue: 3
9 / 3Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Cover Letter
License Agreement
Title Page

Meta-Analysis 


Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Shao-Huan Lan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, Tzu-Liang Hsu.

Abstract
This meta-analysis assessed the efficacy and safety of iclaprim compared with those of vancomycin in the treatment of acute bacterial skin and skin structure infection (ABSSSI). Only randomized controlled trials (RCTs) comparing the effect of iclaprim with vancomycin on adult patients with ABSSSIs were included. A total of 3 RCTs involving 1260 adult patients with ABSSSIs were enrolled. Iclaprim had a non-inferior clinical response rate compared with vancomycin. Similar trend was observed in the following subgroups: major cutaneous abscesses, cellulitis/erysipelas, wound infections, MRSA, MSSA, Streptococcus pyogenes infections. Finally, no differences were observed between iclaprim and vancomycin regarding the risks of any AE, drug-related AE, severe AE, discontinuation of study drug due to AE, and mortality. In conclusion, iclaprim exhibits non-inferior efficacy compared with vancomycin in the treatment of ABSSSI. Additionally, iclaprim was generally as well tolerated as vancomycin.

Key words: Iclaprim, vancomycin, acute bacterial skin and skin structure infection


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shao-Huan Lan
Articles by Chien-Ming Chao
Articles by Shen-Peng Chang
Articles by Li-Chin Lu
Articles by Tzu-Liang Hsu
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. 2022; 8(3): 100-109. doi:10.5455/umj.20220613080211

Web Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. https://www.ulutasmedicaljournal.com/?mno=55300 [Access: October 09, 2023]. doi:10.5455/umj.20220613080211

AMA (American Medical Association) Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. 2022; 8(3): 100-109. doi:10.5455/umj.20220613080211


Vancouver/ICMJE Style

Lan S, Chao C, Chang S, Lu L, Hsu T. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J. (2022), [cited October 09, 2023]; 8(3): 100-109. doi:10.5455/umj.20220613080211


Harvard Style

Lan, S., Chao, . C., Chang, . S., Lu, . L. & Hsu, . T. (2022) Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ulutas Med J, 8 (3), 100-109. doi:10.5455/umj.20220613080211


Turabian Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. 2022. Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. THE ULUTAS MEDICAL JOURNAL, 8 (3), 100-109. doi:10.5455/umj.20220613080211


Chicago Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. "Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials." THE ULUTAS MEDICAL JOURNAL 8 (2022), 100-109. doi:10.5455/umj.20220613080211


MLA (The Modern Language Association) Style

Lan, Shao-Huan, Chien-Ming Chao, Shen-Peng Chang, Li-Chin Lu, and Tzu-Liang Hsu. "Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials." THE ULUTAS MEDICAL JOURNAL 8.3 (2022), 100-109. Print. doi:10.5455/umj.20220613080211


APA (American Psychological Association) Style

Lan, S., Chao, . C., Chang, . S., Lu, . L. & Hsu, . T. (2022) Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. THE ULUTAS MEDICAL JOURNAL, 8 (3), 100-109. doi:10.5455/umj.20220613080211


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About THE ULUTAS MEDICAL JOURNAL

The Ulutas Medical Journal (UMJ) is a 3 monthly (quarterly), open access, double-blind peer-reviewed, an international journal. Writin ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Journal Owner
HAYRİYE ZEHRA ULUTAŞ
Phone: +90 (532) 165 96 39​
E-mail: zehrakenanoglu@hotmail.com​
Address: Alaattin Mah. 30. Ada sok. D11 Blok
No:4 Gungor Uydukent Sitesi  Antakya/HATAY

Editor-In-Chief
KEMAL TURKER ULUTAS, MD, Assc. Prof.
Phone: + 90 (555) 491 35 59​
E-mail: drkemalturker@gmail.com
Address: Alaattin Mah. 30. Ada sok. D11 Blok
No:4 Gungor Uydukent Sitesi  Antakya/HATAY

Publisher Information
SCOPEMED Publishing Co. - TURKEY​
E-mail: scopemed@scopemed.org
Web: https://www.scopemed.com/

 

We welcome your submissions, suggestions, comments, or questions. To reach us, please use one of the methods provided on this page or Email us at ulutasmedicaljournal@gmail.com​

We will respond within 48 to 72 hours.