E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital

Sümeyye Akyuz, Hasan Yasar.

Abstract
Introduction: This study aims to investigate the antibiotic resistance of the agents isolated from cerebrospinal fluid (CSF) samples of adult patients in our hospital for five years to contribute to surveillance data.
Materials and Methods: 121 CSF samples were included in the study between January 2015 and January 2020. Identification of isolates and determination of antibiotic susceptibility profile was performed according to EUCAST criteria with VITEK 2 (bioMérieux, France) automated system.
Results: Microorganisms (n=39) were isolated in 37 (30.6%) 121 cerebrospinal fluid cultures. The most frequently isolated agent is coagulase-negative staphylococci (CNS) by 30.8%. It is followed by Micrococcus spp (%15.4), Streptococcus pneumoniae (%10.3), Klebsiella pneumoniae (%10.3), Acinetobacter baumanii (%10.3), S. aureus (%5.1) and Corynebacterium spp (%5.1). 29 (74.4%) of the agents were isolated from hospitalized patients and 10 (25.6%) outpatients. Oxacillin resistance was found at 83.3% in CNS, and penicillin resistance was found at 25% in Streptococcus pneumoniae. Antibiotics to which K. pneumoniae and A.baumannii isolates are most sensitive are tigecycline and amikacin, respectively.
Conclusion: Different regions and patient populations might cause differences in isolated agents and antimicrobial susceptibility. Retrospective analysis of regional data will assist the clinician in treating patients diagnosed with meningitis, where empirical and agent-oriented therapy is vital.

Key words: Cerebrospinal fluid, antibiotic resistance, bacterial meningitis


 
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How to Cite this Article
Pubmed Style

Akyuz S, Yasar H. The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. Ulutas Med J. 2023; 9(1): 24-29. doi:10.5455/umj.20221215051347


Web Style

Akyuz S, Yasar H. The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. https://www.ulutasmedicaljournal.com/?mno=103771 [Access: December 04, 2023]. doi:10.5455/umj.20221215051347


AMA (American Medical Association) Style

Akyuz S, Yasar H. The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. Ulutas Med J. 2023; 9(1): 24-29. doi:10.5455/umj.20221215051347



Vancouver/ICMJE Style

Akyuz S, Yasar H. The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. Ulutas Med J. (2023), [cited December 04, 2023]; 9(1): 24-29. doi:10.5455/umj.20221215051347



Harvard Style

Akyuz, S. & Yasar, . H. (2023) The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. Ulutas Med J, 9 (1), 24-29. doi:10.5455/umj.20221215051347



Turabian Style

Akyuz, Sumeyye, and Hasan Yasar. 2023. The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. THE ULUTAS MEDICAL JOURNAL, 9 (1), 24-29. doi:10.5455/umj.20221215051347



Chicago Style

Akyuz, Sumeyye, and Hasan Yasar. "The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital." THE ULUTAS MEDICAL JOURNAL 9 (2023), 24-29. doi:10.5455/umj.20221215051347



MLA (The Modern Language Association) Style

Akyuz, Sumeyye, and Hasan Yasar. "The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital." THE ULUTAS MEDICAL JOURNAL 9.1 (2023), 24-29. Print. doi:10.5455/umj.20221215051347



APA (American Psychological Association) Style

Akyuz, S. & Yasar, . H. (2023) The Agents Isolated from Cerebrospinal Fluid and Antibiotic Susceptibility of Adult Patients in a Training and Research Hospital. THE ULUTAS MEDICAL JOURNAL, 9 (1), 24-29. doi:10.5455/umj.20221215051347