E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model

Sami Engin, Aytac Akbas, Volkan Kizilkaya.

Abstract
Introduction: This study aims to compare the efficacy of ADCON-L and free fat graft used to prevent epidural fibrosis in the experimental laminectomy model in rabbits.
Materials and Methods: Thirty adult male New Zealand-type white rabbits weighing 2500-3000 grams were used. Three groups of ten were formed. New subjects and all subjects who replaced subjects who died during the study and follow-up period were sacrificed at the end of the 12th week. Group 1 was determined as the control group. Free fat grafts were placed into the laminectomy areas in group 2. In group 3, ADCON-L was injected into the surgical area. Subjects were sacrificed at week 12. After decalcification, laminectomy zones were taken into routine tissue follow-up for histopathological examination.
Results: When group-1 and group-3 were compared regarding fibroblastic proliferation, there was a statistically significant difference (p<0.001). When group-2 and group-3 were compared, it was determined that fibroblastic proliferation was statistically higher in group-2 (p<0.001). When group-1 and group-3 were compared in terms of collagen amount, the amount of collagen in group-3 was significantly less (p<0.001). When the groups were evaluated statistically regarding the adhesion of the scar tissue to the dura, there was a significant difference between group-1 and group-2 (p<0.01). Adhesion was significantly less in group-3 compared to group-2 (p<0.001).
Conclusion: We concluded that ADCON-L did not cause FBS syndrome. So, ADCON-L is more successful than free fat graft in the prevention of epidural fibrosis after laminectomy in spinal surgery.

Key words: Laminectomy; epidural fibrosis; free fat grafts; ADCON-L; adhesion


 
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How to Cite this Article
Pubmed Style

Engin S, Akbas A, Kizilkaya V. The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. Ulutas Med J. 2023; 9(2): 58-65. doi:10.5455/umj.20230510095834


Web Style

Engin S, Akbas A, Kizilkaya V. The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. https://www.ulutasmedicaljournal.com/?mno=152892 [Access: December 05, 2023]. doi:10.5455/umj.20230510095834


AMA (American Medical Association) Style

Engin S, Akbas A, Kizilkaya V. The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. Ulutas Med J. 2023; 9(2): 58-65. doi:10.5455/umj.20230510095834



Vancouver/ICMJE Style

Engin S, Akbas A, Kizilkaya V. The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. Ulutas Med J. (2023), [cited December 05, 2023]; 9(2): 58-65. doi:10.5455/umj.20230510095834



Harvard Style

Engin, S., Akbas, . A. & Kizilkaya, . V. (2023) The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. Ulutas Med J, 9 (2), 58-65. doi:10.5455/umj.20230510095834



Turabian Style

Engin, Sami, Aytac Akbas, and Volkan Kizilkaya. 2023. The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. THE ULUTAS MEDICAL JOURNAL, 9 (2), 58-65. doi:10.5455/umj.20230510095834



Chicago Style

Engin, Sami, Aytac Akbas, and Volkan Kizilkaya. "The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model." THE ULUTAS MEDICAL JOURNAL 9 (2023), 58-65. doi:10.5455/umj.20230510095834



MLA (The Modern Language Association) Style

Engin, Sami, Aytac Akbas, and Volkan Kizilkaya. "The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model." THE ULUTAS MEDICAL JOURNAL 9.2 (2023), 58-65. Print. doi:10.5455/umj.20230510095834



APA (American Psychological Association) Style

Engin, S., Akbas, . A. & Kizilkaya, . V. (2023) The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model. THE ULUTAS MEDICAL JOURNAL, 9 (2), 58-65. doi:10.5455/umj.20230510095834