Abstract
Introduction: Although vaccination is considered the most effective and essential way to prevent and control COVID-19, immune responses may differ. This study investigated the relationship between vaccination status and gender, noninvasive ventilation (NIV) needs, intubation, length of stay in the intensive care unit (ICU), and mortality.
Materials and methods: During this study, 124 patients aged 18 years and older were admitted to the ICU. We analyzed data from 99 patients with confirmed COVID-19. The patients were divided into three groups according to their vaccination status: vaccinated (≥2 doses of vaccine), partially vaccinated (only one dose of vaccine), or unvaccinated. Vaccination status, age, gender, APACHE II, modified Charlson comorbidity index, need for NIV and intubation, date of intubation, length of stay in the ICU, and ICU outcome were recorded.
Results: A total of 99 patients were analyzed during the study period: 36 (36%) were vaccinated, 8 (8%) were partially vaccinated, and 55 (56%) were not vaccinated. The mean age was 58.7±18.8 years, and 51 (51.5%) were female. Comorbidity was present in 77% (n=76) of the patients. There was no correlation between vaccination status and gender (p=0.564), NIV needs (p=0.810), intubation (p=0.639), length of stay in the ICU (p=0.479), or mortality (p=0.769). The age (p=0.002), modified Charlson comorbidity index (p=0.002), APACHE II score at admission to the ICU (p=0.039), and creatinine (p=0.036) were higher in the vaccinated patients and were associated with mortality.
Conclusion: No correlation was found between vaccination status and gender, need for NIV, intubation, length of stay in the ICU, or mortality

Key words: Vaccines, COVID-19, comorbidity, mortality, critical care