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Original Article 


The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis

Oguz Guvenmez, Asim Kayiklik.


Abstract
Introduction: Herpes simplex virus is a common keratitis agent. There are two different types of virus, type 1 and 2. Type 1 shows three main clinical pictures in cornea: epithelial herpetic keratitis, stromal keratitis, disciform keratitis. The aim of this study is to reduce the duration of herpetic keratitis treatment and eliminate the risk of complications.
Material and Methods: Between January 2017 and January 2018, 29 patients with herpetic keratitis were included in the study. In the first group, the herpetic membrane was removed by a single shot on the herpetic lesion with the yag laser. Then, topically oxytetracycline hydrochloride+polymyxin B sulfate was applied. The second group was treated with topical antiviral therapy (Ganciclovir). After treatment, daily follow-up of patients, vision, tonus, fundus diameters and recovery times were noted and the data were compared statistically.
Results: In group I and group II, the age of the patients did not differ significantly (p> 0.05). In group I and group II, the gender distribution of the patients did not differ significantly (p>0.05). In Group I and Group II, the degree of vision did not differ significantly (p>0.05). In group I and group II, the examination findings were not significant (p>0.05). In group I and group II, recovery time was significantly different (p<0.05).
Conclusion: Oxytetracycline HCl + polymyxin B sulfate may be superior to ganciclovir for treating herpetic epithelial keratitis.

Key words: Herpetic epithelial keratitis, ganciclovir, oxytetracycline HCl, polymyxin B sulfate


 
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Pubmed Style

Guvenmez O, Kayiklik A. The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. Ulutas Med J. 2019; 5(1): 60-64. doi:10.5455/umj.20191024045517

Web Style

Guvenmez O, Kayiklik A. The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. https://www.ulutasmedicaljournal.com/?mno=14201 [Access: March 15, 2025]. doi:10.5455/umj.20191024045517

AMA (American Medical Association) Style

Guvenmez O, Kayiklik A. The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. Ulutas Med J. 2019; 5(1): 60-64. doi:10.5455/umj.20191024045517


Vancouver/ICMJE Style

Guvenmez O, Kayiklik A. The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. Ulutas Med J. (2019), [cited March 15, 2025]; 5(1): 60-64. doi:10.5455/umj.20191024045517


Harvard Style

Guvenmez, O. & Kayiklik, . A. (2019) The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. Ulutas Med J, 5 (1), 60-64. doi:10.5455/umj.20191024045517


Turabian Style

Guvenmez, Oguz, and Asim Kayiklik. 2019. The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. THE ULUTAS MEDICAL JOURNAL, 5 (1), 60-64. doi:10.5455/umj.20191024045517


Chicago Style

Guvenmez, Oguz, and Asim Kayiklik. "The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis." THE ULUTAS MEDICAL JOURNAL 5 (2019), 60-64. doi:10.5455/umj.20191024045517


MLA (The Modern Language Association) Style

Guvenmez, Oguz, and Asim Kayiklik. "The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis." THE ULUTAS MEDICAL JOURNAL 5.1 (2019), 60-64. Print. doi:10.5455/umj.20191024045517


APA (American Psychological Association) Style

Guvenmez, O. & Kayiklik, . A. (2019) The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. THE ULUTAS MEDICAL JOURNAL, 5 (1), 60-64. doi:10.5455/umj.20191024045517


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