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Original Article 


The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation

Hilmi Demirkiran, Hilmi Yetkin, Cemal Kacar, Canser Yilmaz Demir, Arzu Esen Tekeli.


Abstract
Introduction: Preoperative anxiety is a common psychological condition caused by many factors and can affect anesthesia results, postoperative analgesia, and surgery. This study investigated the effects of midazolam and midazolam combined with magnesium sulfate on preoperative anxiety.
Materials and Methods: Sixty patients in the ASA I-II group, aged between 18-60 years, undergoing rhinoplasty operations were included in the study. Patients included in the study were randomly divided into two groups using the sealed envelope method. The first group (Group M; n:30) received 0.02-0.04 mg/kg midazolam in 100 ml isotonic, and the second group (Group MM; n:30) received 2g magnesium sulfate+0.02-0.04 mg/kg midazolam in 100 ml isotonic administered intravenously 15 minutes before surgery. In addition, state-trait anxiety inventory (STAI-TX) was evaluated preoperatively at 0. minutes and postoperative at 0., 3., 6. hours and the visual analog scale (VAS) was evaluated at 0., 3., and 6. hours postoperatively.
Results: 66.7% were female (n:40), 56.7% were ASA-I (n:34), the mean age was 26.17±5.57(18-41) years, and the mean surgery time was 64±12.64 (35-90) minutes. There was no statistically significant difference between the groups regarding age, gender, ASA, and surgical duration of the cases. In addition, heart rate, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and VAS decreased compared to preoperative values, while TOF and STAI-TX values increased in both the M and the MM groups.
Conclusion: Midazolam and midazolam-magnesium sulfate can be safe and effective for preoperative anxiety.

Key words: Preoperative anxiety; midazolam; magnesium sulfate; state-trait anxiety inventory; visual analog scale


 
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How to Cite this Article
Pubmed Style

Demirkiran H, Yetkin H, Kacar C, Demir CY, Tekeli AE. The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. Ulutas Med J. 2023; 9(1): 42-50. doi:10.5455/umj.20230111112358

Web Style

Demirkiran H, Yetkin H, Kacar C, Demir CY, Tekeli AE. The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. https://www.ulutasmedicaljournal.com/?mno=138500 [Access: March 15, 2025]. doi:10.5455/umj.20230111112358

AMA (American Medical Association) Style

Demirkiran H, Yetkin H, Kacar C, Demir CY, Tekeli AE. The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. Ulutas Med J. 2023; 9(1): 42-50. doi:10.5455/umj.20230111112358


Vancouver/ICMJE Style

Demirkiran H, Yetkin H, Kacar C, Demir CY, Tekeli AE. The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. Ulutas Med J. (2023), [cited March 15, 2025]; 9(1): 42-50. doi:10.5455/umj.20230111112358


Harvard Style

Demirkiran, H., Yetkin, . H., Kacar, . C., Demir, . C. Y. & Tekeli, . A. E. (2023) The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. Ulutas Med J, 9 (1), 42-50. doi:10.5455/umj.20230111112358


Turabian Style

Demirkiran, Hilmi, Hilmi Yetkin, Cemal Kacar, Canser Yilmaz Demir, and Arzu Esen Tekeli. 2023. The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. THE ULUTAS MEDICAL JOURNAL, 9 (1), 42-50. doi:10.5455/umj.20230111112358


Chicago Style

Demirkiran, Hilmi, Hilmi Yetkin, Cemal Kacar, Canser Yilmaz Demir, and Arzu Esen Tekeli. "The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation." THE ULUTAS MEDICAL JOURNAL 9 (2023), 42-50. doi:10.5455/umj.20230111112358


MLA (The Modern Language Association) Style

Demirkiran, Hilmi, Hilmi Yetkin, Cemal Kacar, Canser Yilmaz Demir, and Arzu Esen Tekeli. "The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation." THE ULUTAS MEDICAL JOURNAL 9.1 (2023), 42-50. Print. doi:10.5455/umj.20230111112358


APA (American Psychological Association) Style

Demirkiran, H., Yetkin, . H., Kacar, . C., Demir, . C. Y. & Tekeli, . A. E. (2023) The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation. THE ULUTAS MEDICAL JOURNAL, 9 (1), 42-50. doi:10.5455/umj.20230111112358


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