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Original Article 


Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats

Burcu Kasap, Sukru Kasap, Seda Vatansever, Remziye Kendirci, Osman Yilmaz, Meryem Calisir, Ummuhani Ozel Turkcu, Melike Nur Akin, Eren Akbaba, Nilgun Ozturk Turhan.


Abstract
Introduction: The authors investigated the immunohistochemical, histological, and biochemical effects of adipose-derived stem cells (ADSC) which possess antioxidant and anti-inflammatory properties in the ovarian ischemia/ reperfusion rat model.
Materials and Methods: Rats were randomly allocated to sham, ADSC, torsion/detorsion, torsion/detorsion/ADSC groups. ADSCs were micro-injected to torsion/detorsion/ADSC during the detorsion procedure after a 6-h period of torsion. BrdU, caspase-3, TUNEL, eNOS, and iNOS staining were used. Advanced oxidation protein products (AOPPs), superoxide dismutase (SOD) activity, and levels of total sulfhydryl (TSH) were evaluated.
Results: Serum AOPP increased in the torsion/detorsion, tissue and serum AOPP levels in the torsion/detorsion/ ADSC group were decreased. Tissue SOD activity in torsion/detorsion and torsion/detorsion/ADSC groups was significantly decreased compared to the sham group. The iNOS was stronger in the torsion/detorsion group following torsion and detorsion but decreased after ADSC microinjection in the torsion/detorsion/ADSC group. ADSC treatment after torsion-detorsion also reduced caspase-3 immunoreactivity and apoptotic cell number.
Conclusion: ADSC implementation after torsion/detorsion might protect the ovary from ischemia/reperfusion injury.

Key words: Adipose-derived stem cells, Ischemia, Ovary, Rat, Torsion


 
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How to Cite this Article
Pubmed Style

Kasap B, Kasap S, Vatansever S, Kendirci R, Yilmaz O, Calisir M, Turkcu UO, Akin MN, Akbaba E, Turhan NO. Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. Ulutas Med J. 2021; 7(4): 237-247. doi:10.5455/umj.20211019101154

Web Style

Kasap B, Kasap S, Vatansever S, Kendirci R, Yilmaz O, Calisir M, Turkcu UO, Akin MN, Akbaba E, Turhan NO. Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. https://www.ulutasmedicaljournal.com/?mno=134160 [Access: March 15, 2025]. doi:10.5455/umj.20211019101154

AMA (American Medical Association) Style

Kasap B, Kasap S, Vatansever S, Kendirci R, Yilmaz O, Calisir M, Turkcu UO, Akin MN, Akbaba E, Turhan NO. Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. Ulutas Med J. 2021; 7(4): 237-247. doi:10.5455/umj.20211019101154


Vancouver/ICMJE Style

Kasap B, Kasap S, Vatansever S, Kendirci R, Yilmaz O, Calisir M, Turkcu UO, Akin MN, Akbaba E, Turhan NO. Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. Ulutas Med J. (2021), [cited March 15, 2025]; 7(4): 237-247. doi:10.5455/umj.20211019101154


Harvard Style

Kasap, B., Kasap, . S., Vatansever, . S., Kendirci, . R., Yilmaz, . O., Calisir, . M., Turkcu, . U. O., Akin, . M. N., Akbaba, . E. & Turhan, . N. O. (2021) Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. Ulutas Med J, 7 (4), 237-247. doi:10.5455/umj.20211019101154


Turabian Style

Kasap, Burcu, Sukru Kasap, Seda Vatansever, Remziye Kendirci, Osman Yilmaz, Meryem Calisir, Ummuhani Ozel Turkcu, Melike Nur Akin, Eren Akbaba, and Nilgun Ozturk Turhan. 2021. Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. THE ULUTAS MEDICAL JOURNAL, 7 (4), 237-247. doi:10.5455/umj.20211019101154


Chicago Style

Kasap, Burcu, Sukru Kasap, Seda Vatansever, Remziye Kendirci, Osman Yilmaz, Meryem Calisir, Ummuhani Ozel Turkcu, Melike Nur Akin, Eren Akbaba, and Nilgun Ozturk Turhan. "Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats." THE ULUTAS MEDICAL JOURNAL 7 (2021), 237-247. doi:10.5455/umj.20211019101154


MLA (The Modern Language Association) Style

Kasap, Burcu, Sukru Kasap, Seda Vatansever, Remziye Kendirci, Osman Yilmaz, Meryem Calisir, Ummuhani Ozel Turkcu, Melike Nur Akin, Eren Akbaba, and Nilgun Ozturk Turhan. "Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats." THE ULUTAS MEDICAL JOURNAL 7.4 (2021), 237-247. Print. doi:10.5455/umj.20211019101154


APA (American Psychological Association) Style

Kasap, B., Kasap, . S., Vatansever, . S., Kendirci, . R., Yilmaz, . O., Calisir, . M., Turkcu, . U. O., Akin, . M. N., Akbaba, . E. & Turhan, . N. O. (2021) Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats. THE ULUTAS MEDICAL JOURNAL, 7 (4), 237-247. doi:10.5455/umj.20211019101154


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