Abstract
Introduction: This study aimed to investigate the relationship between trace element levels and T2DM in patients from Adıyaman province in southeastern Turkey.
Materials and Methods: This study included 49 healthy subjects and 80 patients diagnosed with T2DM. The study population was divided into healthy controls and patients with T2DM and good glycemic control (GGC) and with T2DM and poor glycemic control (PGC). Biochemical parameters and trace element levels were compared in the three groups.
Results: Fasting blood glucose (FBG) and triglyceride (TG) levels were significantly higher in both diabetic groups and were higher in the PGC than in the GGC group (p<0.05). Low-density lipoprotein cholesterol (LDL-C) and cholesterol (CHO) levels were higher in the PGC than in the control group (p < 0.05). CHO levels were also higher in the PGC than in the GGC group (p<0.05). Elevated manganese (Mn) and chromium (Cr) levels were found in both diabetics, and calcium (Ca) levels were significantly higher in the PGC group than in the controls (p<0.05).
Conclusions: The hyperglycemic and dyslipidemic profiles were significantly elevated in the PGC group compared to the GGC group, suggesting the importance of regular follow-up and treatment in T2DM. The observed positive correlation between T2DM and the levels of the trace elements Mn, Cr, and Ca requires further confirmation in future studies.

Key words: Type II, diabetes mellitus, trace element, glycemic control