Abstract
Background: Helicobacter Pylori (H. Pylori) and ongoing chronic gastric inflammation are the most crucial factors leading to gastric cancer. The serum 25 Hydroxyvitamin D is the fundamental keys to the proper functioning of the immune system and reduction of inflammation. The primary aim of this study is to evaluate the association between the serum level of 25 Hydroxyvitamin D and the presence of H. Pylori as well as gastric inflammation.
Materials and Methods: A total of 91 (18-85 years old) dyspeptic patients having a standard laboratory parameter (hematologic, liver and kidney) without chronic medical problems and were enrolled in this study. During an upper endoscopy, at least four stomach biopsies were taken and evaluated according to Sydney classification. The serum 25-Hydroxyvitamin D level was also calculated at the same time endoscopy.
Results: In population, 48 (52.7%) were H. Pylori positive, while 41 (47.3%) were H. Pylori negative. The mean age, gender, hemoglobin, mean corpuscular volume, mean platelet volume, CRP, ferritin, red cell distribution width, endoscopic findings, and iron were similar in two groups (p<0.05). The mean serum 25-Hydroxyvitamin D level was not different between the two groups (p=0.375). The mean serum 25-Hydroxyvitamin D vitamin level was also not different in gastric inflammation sub-groups (p>0.05). The serum 25-Hydroxyvitamin D levels were similar in groups of H. Pylori positive and negative.
Conclusion: This is the first study investigating the relationship between the serum 25-Hydroxyvitamin D level and H. Pylori as well as gastric inflammation sub-groups. Consequently, we found no relationship between serum 25 Hydroxyvitamin D level and H. Pylori as well as gastric inflammation severity.

Key words: 25-Hydroxyvitamin D, Helicobacter pylori, gastric inflammation, gastritis, Turkey