Primarily, the main fascial pathways in neck region should be studied to understand the spread of necrotizing soft tissue infections to mediastinal compartments. The infection spreads to the mediastinal compartment via three main fascial pathways ( 7 ). These are pretracheal (superficial) ending in the anterior mediastinum, latero pharyngeal (perivascular) ending in middle mediastinum, and retropharyngeal (prevertebral space) ending in the posterior mediastinum ( 8 ).

The retropharyngeal space is the main pathway for oropharyngeal infections to reach the mediastinum.

The infection spreads to the posterior mediastinum via this pathway. This region is a limited space above the hyoid bone and extends up to the T1 vertebra. The cervical prevertebral space has two compartments. The retropharyngeal region in the anterior compartment is the most common dissemination pathway of DNM ( 7 – 10 ).

The posterior compartment is known as the danger space. Following rupture of the alar fascia due to an abscess in retropharyngeal region, the infection spreads to the posterior mediastinal region after reaching the danger space. Since this region extends from the skull base to coccyx, transdiaphragmatic dissemination of the infection has been shown ( 8 ).

The pretracheal pathway is the most superficial of the cervical fascial pathways. It is limited to the anterior trachea and thyroid cartilage ( 6 ) and is the main pathway for spread of thyroid-related infections to the mediastinum. Parietal pleura constitute the inferior part of this region in the pericardium and carina.

The lateropharyngeal pathway is the main pathway followed for draining necrotizing soft tissue infections from the head and neck region to the middle mediastinum. This region consists of the internal jugular veins, carotid arteries, and vagus nerves. Arterial hemorrhage may develop because of perivascular dissemination.

DNM is commonly observed during odontogenic infections of the second and third molar teeth (Ludwig’s angina) and spreads to mediastinum due to negative thoracic pressure along the cervical fascia in the lateropharyngeal region. On the other hand, DNM may further develop due to infections originating from the teeth, parotid glands, and tonsils and otitis, mastoiditis, or epiglottitis rarely occur. Diabetes, advanced age, obesity, peripheral vascular disease, cancer, immunodeficiency, hypoalbuminemia, chronic renal failure, corticosteroid use, and malnutrition are risk factors for DNM ( 8 – 11 ).

Generally, aerobic and anaerobic micro-organisms co-exist (Table 2) and are the most commonly observed causative organisms in one of the three cases. The most commonly detected aerobes are Streptococ pyogenes, Staphylococcus. aureus, Escherichia coli, and Pseudomonas aeruginosa as well as anaerob such as Bacteroides fragilis and Clostridium species ( 12 ).

Early diagnosis of mediastinitis is difficult due to uncertain symptoms. History and physical examinations are important for diagnosis. The most important step in the diagnosis of the disease is to consider NSTI. Deep cervical infections with the abovementioned predisposing factors in the patient’s history should indicate necrotizing fasciitis. Estrera et al. reported the diagnostic criteria, which includes severe oropharyngeal infection residuals, characteristic radiologic findings, necrotizing mediastinitis infection during surgery, and a relationship between DNM and the oropharyngeal process ( 1 – 10 ).

the first 48 h. Mediastinal involvement is typically observed between 12 h and 2 weeks. Retrosternal pain, swelling, redness, rigidity in the neck and anterior thoracic wall (Figure 1 and 2), sepsis symptoms such as shivering and fever, cough, and dyspnea are observed. Dysphagia may develop. Pleural fluid and tamponade may develop because of pleural and/or pericardial involvement. In leukocytosis and sepsis, elevation in the platelet count is observed during the early stage, and if disseminated, intravascular coagulation occurs during later, with a decrease in the platelet count (Figures 1 and 2).

Radiologically, the main finding is Estrea et al. mediastinal extension.

summarized the radiological findings in mediastinitis, which include widening with or without air-fluid level in the retropharyngeal region (Picture 3), mediastinal emphysema (Picture 4), widening of the cervical lordosis, deviation of the tracheal air colon towards the front, pneumothorax due to pleural involvement, and hydropneumothorax.

Computerized tomography (CT) findings include mediastinal air sacs, localized mediastinal fluid collection or abscess collection, decrease in the normal adipose tissue and soft tissue infiltration, no lymphadenopathy, internal jugular vein thrombosis, and carotid pseudoaneurysm (Figure 3 and 4) ( 13 , 14 ).

The main treatment principle in DNM is suitable antibiotic use and surgical drainage. Antibiotic treatment is not effective without surgical drainage and debridement. The necrotic tissues should be debridged and the mediastinal and pleural regions should be irrigated.

The level and method of surgical drainage depends on the infection site. Here, the fourth thoracic vertebra was an important location. If it is above this level, anterior cervical mediastinotomy and placing a soft drain are beneficial; however, in infections below this level, the visceral compartment should be drained as well. Drainage to the pleural space is performed by opening the mediastinal pleura. This can be performed by thoracotomy or video-assisted thoracic surgery (VATS) (Picture 5). If the infection includes bilateral thoracic cavities, bilateral VATS or unilateral posterior thoracotomy and exploration with contralateral VATS or “Clamshell” procedure can be performed for bilateral exploration. The subxiphoid trans thoracic approach may be performed concomitantly with the transcervical approach in anterior mediastinal collections ( 3 ).

Median sternotomy for drainage is not recommended because of the development of DNM posteriorly and difficulty in accessing the site and also the risk of osteomyelitis. The “Clamshell” incision (bilateral thoracotomy and median sternotomy) allows good exploration; however, it is a highly invasive method. With the Clamshell, the bilateral thorax can be reached in one session; however, it is a risky procedure for critical patients (Figure 5).

Hyperbaric oxygen therapy can be initiated after the patient is stabilized and is performed in repeated sessions. The main purpose of this therapy is to prevent infections from spreading by increasing the oxygen perfusion to tissues and also to accelerate healing ( 15 ).

The mortality rate was approximately 50% before antibiotic treatment ( 16 ). The most common cause of mortality is late diagnosis and insufficient drainage ( 17 ). Death may occur due to fulminant sepsis, bleeding, aspiration, metastatic cranial infection, emphysema and purulent pericarditis, and tamponade.