# Metastatic Adrenocortical Carcinoma of the Lung In A Four Years Old Child

## Authors

- Lulu Abdulaziz Alobaid ([ORCID](https://orcid.org/0000-0003-0566-0369)) — Medical intern at King Saud University, Riyadh, Saudi Arabia
- Ilhama Jafari — Associate Consultant at Pediatric Surgery at King Fahad Medical City, Riyadh, Saudi Arabia
- Osama Almosallam ([ORCID](https://orcid.org/0000-0002-9036-7564)) — Fellow at Pediatric Surgery department at Qassim University, Qassim, Saudi Arabia
- Muhammed Amin ur Rahman ([ORCID](https://orcid.org/0009-0007-8758-2347)) — Histopathologist at King Fahad Medical City, Riyadh, Saudi Arabia.
- Abdulwahhab Aljubab — Consultant at Pediatric Surgery at King Fahad Medical City, Riyadh, Saudi Arabia

## Article information

- **Journal:** The Ulutas Medical Journal (Ulutas Med J), ISSN 2149-388X
- **Issue:** Volume 4, Issue 1 (2018), pages 38–43
- **Article type:** Case Report
- **Published online:** 2018-03-28
- **DOI:** [10.5455/umj.20180123053002](https://doi.org/10.5455/umj.20180123053002)
- **Licence:** [CC BY-NC 4.0](https://creativecommons.org/licenses/by-nc/4.0/)
- **Article page:** https://www.ulutasmedicaljournal.com/?mno=289039
- **PDF:** https://www.ulutasmedicaljournal.com/pdf/289039.pdf

## Abstract

Background: Studies of adrenocortical carcinoma is an aggressive rare type of endocrine tumors. It possesses a high mortality rate. This type of carcinomas occurs sporadically, while it could be part of hereditary syndromes. Only limited data is found about the recurrence of these tumors after resection and their prognosis is unclear. Case Presentation: We present a case of a four-year-old boy who presented with virilization symptoms and was referred for further investigation of left abdominal mass. He was cushingoid upon examination. The patient was managed by left nephrectomy and chemotherapy. Upon follow up, the residual mass lesion was seen on CT. Re-resection of the residual tumor was done. Adjuvant mitotane therapy and radiotherapy were started, 7 months later the patient was discovered to have left lung metastasis in which he underwent left lung wedge resection.

## Keywords

Adrenocortical tumors; adrenocortical carcinoma; lung metastasis

## How to cite

Alobaid LA, Jafari I, Almosallam O, Rahman MAU, Aljubab A. Metastatic Adrenocortical Carcinoma of the Lung In A Four Years Old Child. Ulutas Med J. 2018;4(1):38-43. doi:10.5455/umj.20180123053002

## References

1. Breidbart E, Cameo T, Garvin JH, Hibshoosh H, Oberfield SE. Pubertal outcome in a female with virilizing adrenocortical carcinoma. J Pediatr Endocrinol Metab. 1 styczeń 2016;29(4): 503–9. https://doi.org/10.1515/jpem-2015-0123
2. Fassnacht M, Kroiss M, Allolio B. Update in Adrenocortical Carcinoma. J Clin Endocrinol Metab. grudzień 2013;98(12): 4551–64. https://doi.org/10.1210/jc.2013-3020
3. Stewart DR, Morris Jones PH, Jolleys A. Carcinoma of the adrenal gland in children. J Pediatr Surg. luty 1974 [cytowane 30 wrzesień 2016];9(1):59–67. https://doi.org/10.1016/0022-3468(74)90010-4
4. Zaitoon MM, Gary Mackie G. Adrenal cortical tumors in children. Urology. grudzień 1978 [cytowane 30 wrzesień 2016]; 12(6):645–9. https://doi.org/10.1016/0090-4295(78)90424-7
5. Hisada M, Garber JE, Li FP, Fung CY, Fraumeni JF. Multiple Primary Cancers in Families With Li-Fraumeni Syndrome. JNCI J Natl Cancer Inst. 15 kwiecień 1998;90(8):606–11. https://doi.org/10.1093/jnci/90.8.606
6. Stiller CA. International variations in the incidence of childhood carcinomas. Cancer Epidemiol Biomarkers; 1994; 3(4):305 LP-310.
7. Ribeiro RC, Figueiredo B. Childhood adrenocortical tumours. Eur J Cancer. maj 2004 [cytowane 30 wrzesień 2016]; 40(8):1117–26. Metastatic Adrenocortical Carcinoma Alobaid, et al. https://doi.org/10.1016/j.ejca.2004.01.031
8. Wasserman JD, Zambetti GP, Malkin D. Towards an understanding of the role of p53 in adrenocortical carcino genesis. Mol Cell Endocrinol [Internet]. marzec 2012 [cytowane 1 październik 2016];351(1):101–10. https://doi.org/10.1016/j.mce.2011.09.010
9. Patil KK, Ransley PG, McCullagh M, Malone M, Spitz L. Functioning adrenocortical neoplasms in children. BJU Int. 9 kwiecień 2002 [cytowane 1 październik 2016];89(6):562–5. https://doi.org/10.1046/j.1464-410x.2002.02668.x
10. Ciftci BAO, Tanyel FC, Bu N. Adrenocortical Tumors in Children. 2001;36(4):549–54. https://doi.org/10.1053/jpsu.2001.22280
11. Wooten MD, King DK. Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature. Cancer. 1 grudzień 1993;72(11):3145–55. https://doi.org/10.1002/1097-0142(19931201)72:11<3145::aid-cncr2820721105>3.0.co;2-n
12. Srinivas K. Adrenocortical Tumors in Children. J Evol Med Dent Sci. 29 sierpień 2015;4(70):12184–6. https://doi.org/10.14260/jemds/2015/1756
13. Wolthers OD, Cameron FJ, Scheimberg I, Honour JW, Hindmarsh PC, Savage MO. Androgen secreting adreno cortical tumours. Arch Dis Child. styczeń 1999;80(1):46–50.
14. Lau SK, Weiss LM. The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Hum Pathol. czerwiec 2009;40(6):757–68. https://doi.org/10.1016/j.humpath.2009.03.010
15. Klein JD, Turner CG, Gray FL, Yu DC, Kozakewich HP, Perez-Atayde AR. Adrenal cortical tumors in children: factors associated with poor outcome. J Pediatr Surg. czerwiec 2011;46(6):1201–7. https://doi.org/10.1016/j.jpedsurg.2011.03.052
16. Gulack BC, Rialon KL, Englum BR, Kim J, Talbot LJ, Adibe OO. Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). J Pediatr Surg. styczeń 2016;51(1):172–7. https://doi.org/10.1016/j.jpedsurg.2015.10.039
17. McAteer JP, Huaco JA, Gow KW. Predictors of survival in pediatric adrenocortical carcinoma: A Surveillance, Epide-miology, and End Results (SEER) program study. J Pediatr Surg. 30 maj 2013;48(5):1025–31. https://doi.org/10.1016/j.jpedsurg.2013.02.017
18. Union for International Cancer Control. The TNM Classification of Malignant Tumours. 7 th Editio. Gospodaro wicz M, Wittekind Christian, Leslie S, redaktorzy. 2009.
19. Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med. 2007;356. https://doi.org/10.1056/nejmoa063360
20. Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, i in. Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group. J Am Coll Surg. 2016 [cytowane 19 listopad 2016];222(4):480–90. The Ulutas Medical Journal Convenient Online Pdf submission Fast response through peer review No space constraints/color figure charges Immediate publication after acceptance Indexed in CrossREF and Google Scholar To submit your manuscript, please click on https://www.ulutasmedicaljournal.com https://doi.org/10.1016/j.jamcollsurg.2015.12.013
