# Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis

## Authors

- Stefan Kovachev ([ORCID](https://orcid.org/0000-0001-6662-3700)) — Department of General and Oncogynecology, Military Medical Academy, Sofia, Bulgaria
- Rossitza Vatcheva-Dobrevska ([ORCID](https://orcid.org/0000-0002-7353-8552)) — Department of Microbiology and Virology, University Hospital Queen Joanna ISUL, Sofia, Bulgaria

## Article information

- **Journal:** The Ulutas Medical Journal (Ulutas Med J), ISSN 2149-388X
- **Issue:** Volume 2, Issue 1 (2016), pages 20–26
- **Article type:** Original Research
- **Published online:** 2016-03-30
- **DOI:** [10.5455/umj.20160210060327](https://doi.org/10.5455/umj.20160210060327)
- **Licence:** [CC BY-NC 4.0](https://creativecommons.org/licenses/by-nc/4.0/)
- **Article page:** https://www.ulutasmedicaljournal.com/?mno=216967
- **PDF:** https://www.ulutasmedicaljournal.com/pdf/216967.pdf

## Abstract

Introduction: The objective of this study was to establish the efficacy of local probiotic monotherapy for the treatment of bacterial vaginosis. Method: A total of 141 women with bacterial vaginosis, randomized into two groups, were examined. In the first group, 85 women were treated with local probiotic medicine (QD for 10 days) containing Lactobacillus casei var rhamnosus Döderlein (Lcr35®). In the second group, 56 patients received the same local probiotic treatment as those in the first group, in addition to treatment with an oral administration of metronidazol (500 mg tablet BID for 7 days). The efficacy of the monotherapeutic scheme was evaluated by comparing the number of clinical complaints and the results of clinical examinations and microbiological tests in the two groups. Results: One month after the probiotic monotherapy in the first group, the clinical efficacy was 47.1% and the microbiological efficacy was 41.1%. The combined treatment in the second group was more efficacious (clinical efficacy: 89.3%; microbiological efficacy: 76.7%). Conclusions: Thus, our results indicate that local probiotic monotherapy is less effective than combined metronidazole/probiotic scheme for the treatment of bacterial vaginosis.

## Keywords

Lactobacilli; monotherapy; probiotic; vaginal flora

## How to cite

Kovachev S, Vatcheva-Dobrevska R. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. Ulutas Med J. 2016;2(1):20-26. doi:10.5455/umj.20160210060327

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