# Scientific Basis of Cytogenetic Analysis of Miscarriage Material in Invitro Fertilisation/Embryo Transfer Patients

## Authors

- Arzu Yurci ([ORCID](https://orcid.org/0000-0003-4808-9019)) — Department of Obstetrics & Gynecology, Memorial Kayseri Hospital, IVF Center Reproductive Medicine, Kayseri, Turkey
- Simten Genc ([ORCID](https://orcid.org/0000-0003-4446-4467)) — Department of Obstetrics & Gynecology, Okmeydanı Training & Research Hospital, Cemil Tascioglu Hospital, Istanbul, Turkey
- Nur Dokuzeylul Gungor ([ORCID](https://orcid.org/0000-0002-7234-3876)) — Department of Obstetrics & Gynecology, Istanbul Bahcesehir University, Medical Park Goztepe Hospital, Istanbul, Turkey

## Article information

- **Journal:** The Ulutas Medical Journal (Ulutas Med J), ISSN 2149-388X
- **Issue:** Volume 8, Issue 1 (2022), pages 37–44
- **Article type:** Original Article
- **Published online:** 2022-03-09
- **DOI:** [10.5455/umj.20211227090519](https://doi.org/10.5455/umj.20211227090519)
- **Licence:** [CC BY-NC 4.0](https://creativecommons.org/licenses/by-nc/4.0/)
- **Article page:** https://www.ulutasmedicaljournal.com/?mno=139513
- **PDF:** https://www.ulutasmedicaljournal.com/pdf/139513.pdf

## Abstract

Introduction: This study was planned to determine the relationship between the karyotype of either partner of IVF-ET couples who experienced abortion before the 20th gestational week and the cytogenetic findings in product of conception (POC). Materials and Methods: 192 patients who had a miscarriage before 20 weeks of gestation after IVF-ET were included in the study. Cytogenetic analysis was performed using fluorescent in situ hybridization method from chorionic villi in POC. The karyotypes of each parent were compared with the cytogenetic findings obtained from the POC. Results: Cytogenetic anomaly was detected in the POC in 92 (75.4%) of 122 patients who had first abortion, while cytogenetic anomaly was found in only 28(40%) of the 70 patients who had recurrent abortion. Karyotype anomalies were detected in 19 parents, 10 females and 9 males. Cytogentic anomaly was detected in the product of conception of 7 out of 10 cases (70%) with maternal cytogentic anomaly. Cytogenetic anomaly was detected only in 3 miscariage materials of 9 cases with paternal cytogentic anomaly (33.3%). In other words, karyotype anomaly was detected in the POC of 10 of 19 parents whose karyotypes were impaired (52.6%). Five of 10 women with abnormal karyotype had a history of miscarriage before. Likewise, 4 of 9 men with abnormal karyotype previously had a miscarriage. Conclusion: In the presence of a female partner with abnormal karyotype, the risk of cytogenetic anomaly in POC is higher than male partner with karyotype anomaly.

## Keywords

Chromosomal aberrations; Invitro Fertilisation/Embryo Transfer; Miscarriage; Product of conception

## How to cite

Yurci A, Genc S, Gungor ND. Scientific Basis of Cytogenetic Analysis of Miscarriage Material in Invitro Fertilisation/Embryo Transfer Patients. Ulutas Med J. 2022;8(1):37-44. doi:10.5455/umj.20211227090519

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