Abstract
Background: Mean platelet volume (MPV) level is known to increase in diabetes mellitus (DM).
Objective: In this study, the first aim is to examine whether there is a correlation between MPV and hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG). The second aim is to investigate whether a correlation exists between MPV and HbA1c and FPG changes after treatment
Method: In the study, we examined baseline and final HbA1c, MPV and FPGA values of 343 patients. Including the study group (SG) consisted of 169 patients with diabetes whose HbA1c levels decreased %1 and the control group involving 174 patients whose HbA1c levels did not change.
Results: Similar to CG, HbA1c level of SG decreased to 7.58, and MPV level reduced to 8.68. There existed a positive correlation between MPV and HbA1c levels (r=154; p<0.005). Additionally, positive correlation was found between MPV and HbA1c changes (r=216; p=0.005), and MPV and FPG changes (r=245; p=0.001) in SG. Moreover, there was a positive correlation between MPV and HbA1c changes (r=306; p<0.005), and MPV and FPG changes (r=306; p<0.005) in patients underwent insulin treatment.
Conclusion: The change in HbA1c level is similar to MPV level change. The effect of insulin therapy on MPV is significant.

Key words: Mean platelet volume, diabetes mellitus, hemoglobin A1c, fasting plasma glucose.