Open Access and Peer-reviewed Medical Journal
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal


Original Research 


Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones

Ojo Patience Oluwatomilayo, Akinola Busayo Oluwole.

Abstract
Introduction: Diabetes increases the risk of developing neuropathy. In this study, we estimate the effect of Metformin, rosiglitazone, and pioglitazone on the body weight, blood glucose and creatinine level of alloxan-induced diabetic rats.
Materials and Method: Alloxan (150 mg/kg) was used to induce hyperglycemia in fasted rats. Hyperglycaemia was treated with metformin, 150 mg/kg/d; pioglitazone, 3 mg/kg/d; and rosiglitazone, 10 mg/kg/d). The anti-diabetic drugs were administered orally for 28 days. The kidneys were removed when the animals were sacrificed plasma and kidney creatinine level was measured.
Results: There was the reduction in weight of diabetic rats and those administered with metformin while there was an increase in weight of rats administered with rosiglitazone and pioglitazone. There is also reduction in blood glucose level of all treated rats compared with the diabetes control. The effects of creatinine on muscle metabolism generation and serum are insignificant at P≤0.05.
Conclusion: This experiment suggests that short-term diabetes does not have an effect on plasma creatinine level and muscle metabolism of alloxan-induced diabetic rats.

Key words: Plasma glucose, Creatinine, Metformin, Thiazolidinediones


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Ojo Patience Oluwatomilayo
Articles by Akinola Busayo Oluwole
on Google
on Google Scholar
Article Statistics
 Viewed: 298
Downloaded: 131
Cited: 0


How to Cite this Article
Pubmed Style

Oluwatomilayo OP, Oluwole AB. Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. Ulutas Med J. 2018; 4(2): 73-77. doi:10.5455/umj.20180116075446


Web Style

Oluwatomilayo OP, Oluwole AB. Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. http://www.ulutasmedicaljournal.com/?mno=288358 [Access: September 25, 2018]. doi:10.5455/umj.20180116075446


AMA (American Medical Association) Style

Oluwatomilayo OP, Oluwole AB. Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. Ulutas Med J. 2018; 4(2): 73-77. doi:10.5455/umj.20180116075446



Vancouver/ICMJE Style

Oluwatomilayo OP, Oluwole AB. Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. Ulutas Med J. (2018), [cited September 25, 2018]; 4(2): 73-77. doi:10.5455/umj.20180116075446



Harvard Style

Oluwatomilayo, O. P. & Oluwole, A. B. (2018) Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. Ulutas Med J, 4 (2), 73-77. doi:10.5455/umj.20180116075446



Turabian Style

Oluwatomilayo, Ojo Patience, and Akinola Busayo Oluwole. 2018. Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. THE ULUTAS MEDICAL JOURNAL, 4 (2), 73-77. doi:10.5455/umj.20180116075446



Chicago Style

Oluwatomilayo, Ojo Patience, and Akinola Busayo Oluwole. "Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones." THE ULUTAS MEDICAL JOURNAL 4 (2018), 73-77. doi:10.5455/umj.20180116075446



MLA (The Modern Language Association) Style

Oluwatomilayo, Ojo Patience, and Akinola Busayo Oluwole. "Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones." THE ULUTAS MEDICAL JOURNAL 4.2 (2018), 73-77. Print. doi:10.5455/umj.20180116075446



APA (American Psychological Association) Style

Oluwatomilayo, O. P. & Oluwole, A. B. (2018) Estimation of Plasma Glucose and Creatinine Level in Alloxan-induced Diabetic Wistar Rats treated with Metformin and Thiazolidinediones. THE ULUTAS MEDICAL JOURNAL, 4 (2), 73-77. doi:10.5455/umj.20180116075446








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


CrossRef

ScopeMed

Google Scholar

TUBITAK Dergipark

Index Scholar

Index Copernicus


ABOUT JOURNAL
POLICIES and STATEMENTS

The articles in Ulutas Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.