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The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

Alexander E Berezin.

Abstract
Previous clinical, observation and epidemiologic studies have demonstrated strong association between serum uric acid (SUA) and cardiovascular disease (hypertension, heart failure, asymptomatic atherosclerosis), metabolic states (abdominal obesity, diabetes mellitus, metabolic syndrome, insulin resistance) and kidney disease. There is a large body of evidence regarding the role of SUA as predictor of CV events and CV mortality in general population and individuals with established CV disease and metabolic diseases. However, SUA may exhibit protective effects on endothelium and vasculature as well as attenuate endogenous repair system through mobbing and differentiation of cell precursors. Although SUA lowering drugs are widely used in patients with symptomatic hyperuricemia and gout beyond their etiologies, there is no agreement of SUA below target level 6.0 mg/dL in asymptomatic individuals with kidney injury and CV disease and data of ones are sufficiently limited. The short communication is depicted on the controversial role of SUA as primary cell toxicity agent and secondary cell protector against hypoxia, ischemia and apoptosis.

Key words: Serum uric acid, cardiovascular disease, metabolic states, outcomes, biomarker


 
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Pubmed Style

Alexander E Berezin. The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. Ulutas Med J. 2017; 3(3): 54-56. doi:10.5455/umj.20170608022350



Web Style

Alexander E Berezin. The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. www.scopemed.org/?mno=268872 [Access: November 23, 2017]. doi:10.5455/umj.20170608022350



AMA (American Medical Association) Style

Alexander E Berezin. The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. Ulutas Med J. 2017; 3(3): 54-56. doi:10.5455/umj.20170608022350



Vancouver/ICMJE Style

Alexander E Berezin. The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. Ulutas Med J. (2017), [cited November 23, 2017]; 3(3): 54-56. doi:10.5455/umj.20170608022350



Harvard Style

Alexander E Berezin (2017) The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. Ulutas Med J, 3 (3), 54-56. doi:10.5455/umj.20170608022350



Turabian Style

Alexander E Berezin. 2017. The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. THE ULUTAS MEDICAL JOURNAL, 3 (3), 54-56. doi:10.5455/umj.20170608022350



Chicago Style

Alexander E Berezin. "The Controversial Role of Serum Uric Acid in Cardiovascular Diseases." THE ULUTAS MEDICAL JOURNAL 3 (2017), 54-56. doi:10.5455/umj.20170608022350



MLA (The Modern Language Association) Style

Alexander E Berezin. "The Controversial Role of Serum Uric Acid in Cardiovascular Diseases." THE ULUTAS MEDICAL JOURNAL 3.3 (2017), 54-56. Print. doi:10.5455/umj.20170608022350



APA (American Psychological Association) Style

Alexander E Berezin (2017) The Controversial Role of Serum Uric Acid in Cardiovascular Diseases. THE ULUTAS MEDICAL JOURNAL, 3 (3), 54-56. doi:10.5455/umj.20170608022350








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